Talazoparib capsules contain the active ingredient Talazoparib, a targeted anti-cancer medication belonging to the class of PARP (Poly ADP-Ribose Polymerase) inhibitors. It is used in the treatment of certain types of advanced breast and prostate cancers associated with BRCA or other homologous recombination repair (HRR) gene mutations.

Talazoparib works by preventing cancer cells from repairing damaged DNA, leading to cancer cell death while limiting damage to normal cells.

Available strengths:

Talazoparib 0.25 mg capsules

Talazoparib 1 mg capsules

These lower strengths are generally used for dose adjustments or in patients requiring modified dosing due to side effects or kidney function considerations.

Talazoparib is prescribed for:

Germline BRCA-mutated (gBRCAm), HER2-negative, locally advanced or metastatic breast cancer.

HRR gene-mutated metastatic castration-resistant prostate cancer (mCRPC) (as per physician recommendation and regional approval).

Treatment should only be initiated after genetic confirmation of mutation status.

Talazoparib inhibits the PARP enzyme involved in DNA repair. Cancer cells with BRCA mutations already have impaired DNA repair mechanisms. By blocking PARP, Talazoparib further prevents repair, causing cancer cells to die.

The usual recommended starting dose is 1 mg once daily (as prescribed by the oncologist).

0.25 mg and 0.1 mg capsules are commonly used for dose reductions in case of side effects.

Swallow the capsule whole with water.

Can be taken with or without food.

Do not crush, chew, or open the capsule.

Always follow your doctor’s instructions strictly.

Possible Side Effects

Common side effects include:

Anaemia (low red blood cells)

Neutropenia (low white blood cells)

Thrombocytopenia (low platelets)

Fatigue

Nausea

Headache

Loss of appetite

Vomiting

Diarrhoea

Serious but rare risks:

Severe bone marrow suppression

Myelodysplastic syndrome (MDS)

Acute Myeloid Leukaemia (AML)

Contact your doctor immediately if you experience unusual bruising, bleeding, persistent fever, or severe weakness.

Inform your doctor if you are taking:

P-glycoprotein (P-gp) inhibitors

Other chemotherapy agents

Herbal supplements

Over-the-counter medications

Dose adjustment may be required.

Store at 20–25°C (room temperature)

Keep in original packaging

Protect from moisture

Keep out of reach of children

Talazoparib is a prescription-only anticancer medication and should only be used under the supervision of a qualified oncologist.