Revumenib tablets contain the active substance Revumenib. It is an antineoplastic medicine that belongs to the class of menin inhibitors. This medication is used in the treatment of certain types of acute leukemia associated with KMT2A gene rearrangement (KMT2Ar) or NPM1-mutated acute leukemia. Revumenib works by targeting the menin-KMT2A interaction that drives leukemia cell growth.

Do not take Revumenib tablets if you are allergic to Revumenib or any other ingredients of this medicine. Before starting treatment, inform your healthcare provider if you have liver disease, heart rhythm problems, electrolyte imbalance, or any other serious medical conditions.

Notify your doctor if you are taking antifungal medicines, antibiotics, antivirals, seizure medications, or herbal supplements, as they may interact with Revumenib. Inform your doctor immediately if you are pregnant, planning to become pregnant, or breastfeeding.

Effective contraception should be used during treatment and for a certain period after completing therapy, as Revumenib may harm an unborn baby.

This medication is generally prescribed under specialist supervision and is not recommended for children unless advised by a qualified healthcare professional.

Relapsed or refractory acute leukemia with KMT2A gene rearrangement (KMT2Ar).

NPM1-mutated acute leukemia.

Certain acute myeloid leukemia (AML) subtypes under specialist guidance.

Revumenib works by inhibiting the interaction between menin and KMT2A proteins, which are responsible for the abnormal growth of leukemia cells.

By blocking this pathway, Revumenib helps:

• Slow down the growth of leukemia cells

• Induce differentiation of malignant cells

• Reduce the progression of leukemia

Take Revumenib tablets exactly as prescribed by your physician.

• Swallow the tablets whole with water.

• Do not crush, chew, or split the tablets unless advised by your doctor.

• Take the medicine at the same time each day to maintain consistent drug levels in the body.

The dosage may vary depending on:

• Body weight

• Medical condition

• Response to treatment

• Other medicines being taken

Always follow your physician's instructions.

Common side effects include:

• Nausea

• Vomiting

• Diarrhea

• Fatigue

• Fever

• Decreased appetite

• Headache

• Low blood cell counts

• Electrolyte imbalance

Serious side effects may include:

• Differentiation syndrome

• QT interval prolongation (heart rhythm changes)

• Severe infections

• Liver enzyme abnormalities

Seek medical attention immediately if severe symptoms occur.

Inform your healthcare provider about all medicines you take, including prescription medicines, over-the-counter drugs, vitamins, and herbal supplements.

Some medicines that may interact with revumenib include the following:

• Strong CYP3A4 inhibitors (e.g., Ketoconazole, itraconazole, and Clarithromycin)

• Strong CYP3A4 inducers (e.g., Rifampicin, Carbamazepine, Phenytoin)

• Certain antifungal medications

• Certain antibiotics and antiviral medicines

These medicines may affect how Revumenib works or increase the risk of side effects.

Store Revumenib tablets at room temperature (15°C – 30°C).

Keep the tablets in the original container to protect them from moisture and light.

Keep out of the sight and reach of children.

Do not use the medicine after the expiry date printed on the packaging.

Medical Monitoring:

Patients receiving Revumenib therapy should undergo regular monitoring, including blood tests and cardiac assessments.

Dosage Compliance:

Take the medicine exactly as prescribed. Do not skip doses or stop treatment without consulting your doctor.

Report Symptoms Early:

Inform your healthcare provider immediately if you experience fever, breathing problems, rapid weight gain, or swelling, as these may indicate differentiation syndrome.

Drug Interactions:

Always inform your doctor about any new medicines before starting them during Revumenib therapy.